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KMID : 0381920100400040211
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Korean Journal of Microscopy
2010 Volume.40 No. 4 p.211 ~ p.218
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The Oxytocinergic Neurons in Hypothamo-hypophysial Tract The Oxytocinergic Neurons in Hypothamo-hypophysial Tract
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Byun Kyung-Hee
Oh Jee-Hyun
Jo Seung-Mook
Lee Bong-Hee
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Abstract
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The mammalian ovary is innervated by sympathetic and sensory neurons which contribute to regulating several aspects of ovarian function, including blood flow, steroidogenesis and follicular development. The existence of a neural connection between central neurons and the ovary has been rarely reported, but the mechanism underlying integration of ovarian activity to broader neuroendocrine responses has not been reported. We have now used a viral transneuronal tracing technique combined with a conventional retrograde labeling procedure of CT-HRP to demonstrate that oxytocin-producing neurons of the hypothalamus are synaptically connected to the ovary. Since ovarian activity is suppressed but the activity of oxytocin neurons is increased during breast feeding. Our finding that the oxytocinergic neural connection is likely to provide a direct transsynaptic mechanism by which the central nervous system maintains the state of infertility that accompanies lactation in mammals.
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KEYWORD
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Ovary, Pituitary, Oxytocinergic neurons, CNS pathway, Pseudorabies virus
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